Biology of sporadic and hereditary myeloproliferative diseases
Aims
The aims of MPN&MPNr-EuroNet’s tenth meeting to be held in Zagreb, Croatia, on April 9-10, 2015 are:
- to share information on the newest developments in MPNs and related congenital diseases, hereditary erythrocytosis and hereditary thrombocytosis;
- to exchange and diffuse the latest information and guidelines on the molecular assays developed for diagnosis or research in laboratories working on MPNs and related diseases across Europe;
- to provide guidelines for the molecular diagnosis of MPN, hereditary erythrocytosis and hereditary thrombocytosis;
- to discuss and plan for the various tasks and objectives of the three MPN∓MPNr-EuroNet working groups (WG);
- to help and encourage young scientists to pursue a career dedicated to MPNs.
To do so, abstracts will be selected for short talks in the general and working group sessions. Posters will be presented during the whole length of the meeting.
Plenary sessions will cover the newest knowledge in MPNs. Each WG will convene under the direction of the WG chairs. New participants are encouraged to become actively involved in specific WG tasks.
Objectives
Participants to the tenth MPN&MPNr-EuroNet meeting will have the opportunity to hear from the best experts about the newest developments in the molecular diagnosis of MPNs and related congenital/hereditary diseases. They will have the opportunity to present their own work and original diagnostic assays, and exchange with colleagues and experts on the newest genes and techniques of interest in the field of MPNs, congenital erythrocytosis and hereditary thrombocytosis. By joining one or more of MPN&MPNr-EuroNet working groups, they will be able to contribute actively, productively and durably in innovation, optimization and standardization of the biological diagnosis of MPNs and related congenital diseases in Europe.
Keywords
molecular diagnosis, myeloproliferative neoplasms, congenital erythrocytosis, hereditary thrombocytosis, standardization, European network
More info
Click on the following link to get more info about MPN&MPNr-EuroNet.
Abstract Submission
Participants are encouraged to submit an abstract in relation to the diagnosis of MPNs, new mutations in MPNs, the histopathology of MPNs, the pathogenesis of MPNs, inflammation in MPNs, congenital erythrocytosis, hereditary thrombocytosis, and the JAK/STAT and other signalling pathways of interest in MPNs. Early stage researchers and junior biologists and clinicians are especially encouraged to submit abstracts.
Abstracts should be composed as follows:
- Title
- Names of co-authors
- Institutions and addresses
- E-mail address of corresponding author
- Text (body of text less than 2000 characters, including spaces).
All abstracts will be put together in an Abstract Book that will be distributed to participants during the meeting.
The deadline for submission of abstracts is February 28th, 2015.
In order to submit an abstract, participants should first be registered, then, being logged in, choose Abstract in the menu bar on Registration page.
Scholarships
MPN&MPN-EuroNet offers scholarships to early state researchers (ESRs) and biologists : PhD students, researchers, biologists or clinicians who received their MD or PhD degree less than 8 years ago. To apply for a scholarship, ESRs must submit an abstract following the on-line procedure, and send a letter of motivation and their curriculum vitae to Dr. Sylvie Hermouet.
Please upload here the CV template .
The deadline for application to a scholarship is February 28th, 2015.
Applicants will be informed of the decision regarding attribution of scholarship via E-mail by March 7th, 2015.
Reimbursements of scholarship recipients
To allow sufficient time for treating the files of all individuals applying for reimbursement, registration should be done before March 16th, 2015.
Biology of Sporadic and Hereditary Myeloproliferative Diseases
THURSDAY April 9th, 2015 |
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| 08:30 – 09:00 | Welcome and Registration | |
| 09:00 – 10:45 | WG1 session: Mutation detection and validation | Chair: Susanne Schnittger (DE) |
| 09:00 – 09:10 | HRM testing of CALR mutations in JAK2V617F/MPLW515 double negative cases. | François Girodon (FR) |
| 09:10 – 09:20 | CALR mutations in JAK2-unmutated PV. | François Girodon (FR) |
| 09:20 – 09:30 | CALR mutations in splanchnic vein thrombosis. | Stephen Langabeer (IE) |
| 09:30 – 09:40 | Update on a large cohort studied for CALR mutations. | Susanne Schnittger (DE) |
| 09:40 – 09:50 | How NGS can improve diagnosis of JAK2/MPL/CALR mutation analysis. | Susanne Schnittger (DE) |
| 09:50 – 10:10 | Identification of genetic alterations in triple negative ET patients with TruSight Myeloid Sequencing Panel. | Julia Asp (SE) |
| 10:10 – 10:35 | General discussion on methods and quality control | |
| 10:35 – 10:45 | TERT rs2736100_C polymorphism as predisposition factor For myeloproliferative neoplasms | Hanjalka Andrikovics (HU) |
| 10:45 – 11:15 | Coffee/tea | |
| 11:15 – 12:45 | WG2 session: Mutation quantification and MRD | Chair: Niels Pallisgaard (DK) |
| 11:15 – 11:35 | CALR mutation detection and monitoring by qPCR | Lasse Kjær (DK) |
| 11:35 – 11:55 | MPL assays and quality assurance | Elisabeth Oppliger (CH) |
| 12:00 – 12:20 | Quantitative JAK2 quality assurance data | Julia Asp (SE) |
| 12:25 – 12:45 | Can dPCR be used in MPN mutation detection and monitoring? | Niels Pallisgaard (DK) |
| 12:45 – 12:55 | Evading capture by JAK2 V617F Minimal Residual Disease monitoring: An illustrative Case Report | Stephen Langabeer (IE) |
| 13:00 – 14:30 | Lunch and Free Time for Informal Discussions and Networking | |
| 14:30 – 16:30 | WG3 session: Hereditary Erythrocytosis and Thrombocytosis | Chair: Mary Frances McMullin (UK) |
| 14:30 – 14:50 | Thrombocytosis associated with germline MPL mutation | Mathias Vilaine (FR) |
| 14:50 – 15:10 | The thrombopoietin receptor P106L mutation functionally separates receptor signaling activity from thrombopoietin homeostasis | Clemens Stockklausner (DE) |
| 15:10 – 15:25 | Bleeding and thrombosis in Chuvash polycythemia – a quest for mechanisms | Maria Astrom (SE) |
| 15:25 – 15:40 | Congenital erythrocytosis: Diagnosis and more | Betty Gardie (FR) |
| 15:40 – 15:55 | NGS: new mutations and genes | Celeste Bento (PT) |
| 15:55 – 16:10 | An old gene rediscovered | Mary Frances McMullin (UK) |
| 16:10 – 16:25 | More new genes and mutations | Holger Cario (DE) |
| 16:25 – 16:35 | A single center study of a large cohort of patients with erythocytosis: Differences between idiopathic/congenital erythrocytosis and polycythemia vera | Maria Luigia Randi (IT) |
| 16:35 – 17:00 | Coffee/tea break | |
| 17:00 – 18:00 | Business sessions in small groups | |
| Free Time for Informal Discussions and Networking | ||
| 3 rooms avalaible for discussions in small groups | ||
| 20:00 – 22:00 | Gala Dinner | |
FRIDAY April 10th, 2015 |
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| 08:30 – 10:15 | Special Session I: Inflammation | Chair : Rajko Kušec (CRO) |
| 08:30 – 09:05 | TGF-β and urokinase type-plasminogen activator interplay in cancer and inflammation | Juan F. Santibanez (RS) |
| 09:05 – 09:40 | Role of TGF-β1 in the intrinsic alterations of the mesenchymal/osteoblastic niche in Primary MyeloFibrosis | Marie-Caroline Le Bousse-Kerdiles (FR) |
| 09:40 – 10:15 | Deficiency of the ubiquitin ligase ITCH promotes chronic inflammation, mislocalization of NF-E2 and an MPN phenotype with leukemic transformation | Jonas S. Jutzi, Heike L. Pahl (DE) |
| 10:15 – 10:45 | Coffee/Tea break | |
| 10:45 – 12:30 | Special Session II : Inflammation and MPN Management | Chair : François Girodon (FR) |
| 10:45 – 11:20 | Microarray and proteomic studies of inflammation biomarkers in MPNs | Vladan Cokic (RS) |
| 11:20 – 11:55 | Inflammation in MPNs: Over-view and Summary | Sylvie Hermouet (FR) |
| 11:55 – 12:30 | Impact of new genetics on MPN management | Rajko Kušec (CRO) |
| 12:30 – 14:00 | Lunch and Free Time for Informal Discussions and Networking | |
| 14:00 – 15:30 | General business session | Chair: Sylvie Hermouet (FR) |
| 14:00 – 14:20 | MPN&MPNr-EuroNet 11th meeting April 28-29, 2016, Poznan, Poland |
Marzena Wojtaszewska (PL) |
| 14:20 – 14:40 | Proposals for new collaborative studies | Open |
| 14:40 – 14:55 | The Hemadimor Project | Vladan Cokic (RS) |
| 14:55 – 15:30 | Scientific Communications Publications Budget Website |
Sylvie Hermouet (FR) |
| 15:30 | Meeting Adjourn | |
42 registered participants on 07-12-2019
| # | Name | Affiliation | Country |
|---|---|---|---|
| 1 | Sylvie HERMOUET | Inserm UMR892 | France |
| 2 | Maruska Marusic | Dubrava University Hospital | Croatia |
| 3 | Clemens Stockklausner | Heidelberg University Hospital | Germany |
| 4 | Francois Girodon | CHU DIJON | France |
| 5 | Betty GARDIE | Ecole Pratique des Hautes Etudes | France |
| 6 | Jonas Jutzi | Univ. of Freiburg | Germany |
| 7 | Heike Pahl | University Medical Center Freiburg | Germany |
| 8 | Mathias Vilaine | Inserm U892 / CNRS 6299 | France |
| 9 | Marzena Wojtaszewska | Poznań University of Medical Sciences | POLAND |
| 10 | Svetlana Treglazova | National Research Centre of Hematology | Russia |
| 11 | Holger Cario | University Medical Center Ulm | Germany |
| 12 | Stephen Langabeer | St. James’s Hospital | Ireland |
| 13 | Juan Santibanez | Institute for Medical Research | Serbia |
| 14 | Marie-Caroline Le Bousse-Kerdilès | Inserm U1197 | FRANCE |
| 15 | Margareta Radić Antolic | Hematology | Croatia |
| 16 | Adhamjon Addullaev | National Research Center for Hematology | Russia |
| 17 | Andrey Sudarikov | National Research Center for Hematology | Russia |
| 18 | Anait Melikyan | National Research Center for Hematology | Russian Federation |
| 19 | Rajko Kusec | Dubrava University Hospital and Medical School | Croatia |
| 20 | Renata Zadro | University Hospital Center Zagreb | Croatia |
| 21 | Vladan Cokic | Institute for Medical Research | Serbia |
| 22 | Niels Pallisgaard | Vejle Hospital | Denmark |
| 23 | Lasse Kjaer | Roskilde Hospital | Denmark |
| 24 | Vibe Skov | Roskilde Hospital | Denmark |
| 25 | Julia Asp | Sahlgrenska University Hospital | Sweden |
| 26 | Ivana Horvat | University Hospital Center Zagreb | Croatia |
| 27 | Hajnalka Andrikovics | Hungarian National Blood Transfusion Service | Hungary |
| 28 | Edoardo Peroni | Università degli Studi di Padova | Italia |
| 29 | Maria Luigia Randi | University of Padua | Italy |
| 30 | Morten Andersen | Rigshospitalet | Denmark |
| 31 | Mary Frances McMullin | Queens universiy Belfast | N. Ireland |
| 32 | Jiri Schwarz | The Institute of Hematology and Blood Transfusion | Czech Republic |
| 33 | Susanne Schnittger | Munich Leukemia Laboratory | |
| 34 | Marta Vorland | Haukeland University Hospital | Norway |
| 35 | Maria Åström | Örebro University | Sweden |
| 36 | Celeste Bento | University Hospital Center Coimbra | Portugal |
| 37 | Elisabeth Oppliger Leibundgut | University Hospital Bern | Switzerland |
| 38 | Véronique LALOUX | QIAGEN | France |
| 39 | Maria Caterina Putti | University of Padua | Italy |
| 40 | Maria Caterina Putti | University of Padua | Italy |
| 41 | Amina Kozaric | Clinical Center Sarajevo | Bosnia |
| 42 | Aleksandar Eftimov | University Skopje Ss. Cyril & Methodius | Macedonia |
Conference location
| DoubleTree by Hilton Hotel Zagreb
Ulica grada Vukovara 269a Phone: +385 1 6001900 |
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DoubleTree by Hilton Hotel Zagreb is located on Ulica grada Vukovara, in the heart of Zagreb’s business district and two kilometers from the historic city center. It is an award-winning Zagreb hotel set within the Green Gold complex, offering great shopping and dining options. Guests can easily reach Zagreb’s historic centre and visit its numerous sights.
For booking your room please see below the Accommodation section.
Contact with the organizers: Before contacting the organizers, please read carefully all information provided on the website. The meeting organization local contact persons are Prof. Rajko Kusec, e-mail rkusec@irb.hr, and Dr. Maruska Marusic, e-mail marusicmaruska@gmail.com.
Questions may also be asked through the Contact webpage. Thank you for your understanding and co-operation.
How to register, submit a contribution, pay registration fees, get invoice? For registration, submission of contribution … select Registration on the menu bar.
How to get there?
Visa regime in Croatia
Croatia has been part of the European Union since July 2013.
Currency
Currency in Craotia is the Croatian Kuna (HRK).
The current exchange rate (as of November 2014) is 1 € = 7.65 HRK.
As the official currency, the Croatian Kuna is the only possible currency to use when paying. Many exchange offices are available and easy to reach everywhere in the centre.
Travelling to Zagreb by air …
The main airport is Zagreb International Airport.
Transportation from the Zagreb International Airport to the DoubleTree by Hilton Hotel Zagreb
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- Taxi
It takes approximately 25 – 30 minutes (40 minutes in heavy traffic) to reach the centre. The price for taxi is approx. 200-250 HRK (26 €) from the Zagreb International Airport to the DoubleTee by Hilton Hotel. Please check the price with the taxi driver at entering the cab. Departure points are situated in front of arriving halls.
Or
Taxi’s can be pre-booked via the hotel’s e-mail zagcr.fom@hilton.com, at a rate of approximately 14,50 €. Please contact the hotel directly. - Public transport
You can reach Zagreb main bus station from the airport with the airport shuttle bus which departs to the city every 30 minutes, from 7 am to 8 pm. Cost of a bus ticket is approx 4 €. From there, please see bus directions.
- Taxi
Travelling to Zagreb by car …
Find here all needed information.
Travelling to Zagreb by train …
When arriving to the main train station you can reach the hotel directly by taking the tram number 2 towards Savisce and exit at the fifth stopping. On your left side you will see the hotel. The trip lasts approximately 10 minutes. Tram tickets can be bought at any newspaper stand and cost approx. 1.50 €.
Travelling to Zagreb by bus …
When exiting the main bus station take tram number 2 towards Savisce and exit at the second stop. The hotel is on your left hand side. It will take you approximately 5 minutes. Tram tickets can be bought at any newspaper stand and cost approx. 1.50 €. The hotel is also reachable by foot with a 10 minute walk.
Public transport in Zagreb
There is dense network of trams and buses. Tickets are universal, can be bought at any newspaper stand and cost approx. 1.50 €.
Accommodation
Each participant has to make his/her own room reservation.
It is recommended to stay at:
- DoubleTree by Hilton Hotel Zagreb where the main event will take place.
DoubleTree by Hilton Zagreb features elegantly decorated rooms and suites. The bright and spacious rooms and suites are fitted with floor-to-ceiling windows and stylish furniture. LCD satellite TV, free Wi-Fi and air conditioning come with each unit. Oxbo Grill Restaurant&Bar offers adventurous cuisine based on grilled meat and fish dishes. Buffet-style breakfast is served each morning. Set within the Green Gold Complex, DoubleTree by Hilton Zagreb is just steps away from a vibrant shopping area.
Variety of massages and beauty treatments are offered in the spa centre, while the modern gym area features panoramic city views.
Special rate for this meeting is 135 € / night.
To get this benefit make reservation before February 28, 2015.
For booking your room, please fill in the Room Reservation form .doc file or .pdf file and send it to marina.doroslovac@hilton.com.
Other recommended hotels in walking distance from the conference venue:
Zagreb - Touristic information
Zagreb is an old Central European city. For centuries it has been a focal point of culture and science, and now of commerce and industry as well. When the Croatian people achieved their independence in 1991, Zagreb became a capital – a political and administrative centre for the Republic of Croatia but it is also the hub of the business, academic, cultural, artistic and sporting worlds in Croatia. Zagreb can offer its visitors the Baroque atmosphere of the Upper Town, picturesque open-air markets, diverse shopping facilities, an abundant selection of crafts and a choice vernacular cuisine. Zagreb is a city of green parks and walks, with many places to visit in the beautiful surroundings. In spite of the rapid development of the economy and transportation, it has retained its charm, and a relaxed feeling that makes it a genuinely human city.
